This article examines the interactive approach of the Islamic Republic of Iran with the International Atomic Energy Agency. The purpose of this research is to explain the different dimensions of this interaction, identify the factors affecting it, and evaluate the results and achievements. Using qualitative research methods and documentary analysis, the theoretical framework of international interactions and the role of international organizations were first examined, and then, The evolution of Iran's interaction with the Agency from before the Islamic Revolution to now, It will be analyzed with an emphasis on sensitive and key periods such as the pre-JCPOA nuclear program period, the JCPOA implementation period, and after the US withdrawal from it. The findings indicate that Iran's interactive approach with the Agency has been a function of multiple factors such as domestic political conditions, international pressures, foreign policy objectives, and security considerations. This interaction has at times tended toward greater cooperation and transparency, and at other times has been limited or challenged by distrust and heightened tensions. The article also mentions the Agency's role in monitoring Iran's nuclear activities, verifying commitments, and providing technical and training assistance. While critically evaluating the Agency's performance, it addresses the challenges and opportunities facing Iran's interaction with this international organization. Despite the Islamic Republic of Iran's full implementation of its obligations under the JCPOA through constructive and continuous engagement with the Agency in order to protect its national rights and interests, Promoting mutual trust, including increasing transparency in nuclear activities, strengthening technical and educational cooperation, and resolving remaining issues and ambiguities through dialogue and negotiation. But the United States and Europe did not adhere to any of their commitments in the JCPOA agreement This led to a clear violation of international conventions and norms, as well as the weakening of the global order based on the UN Charter.